Cytodynamic Reactivity of the Mesothelium

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Abstract
The cytodynamic reactivity of rat pleural mesothelium to intrairacheally administered dust suspensions of synthetic or natural chrysotile in saline was examined, employing the tritiated thymidine technique. Natural chrysotile brought about a marked increase in the labeling Index of the visceral pleural mesothelium as early as five and seven days after the treatment In addition, the loss of label from this group, after the administration of tritiated thymidine at the time of treatment, occurred more rapidly than in control saline-treated animals. A similar, but lesser decline in the labeling index was noted in rats treated with synthetic chrysotile. These observations Indicate that the pleural mesothelium dssplays a high degree of sensitivity to chrysotile asbestos, even when administered by the intratracheal route.

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