Epac: a new cAMP target and new avenues in cAMP research
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- 1 September 2003
- journal article
- research article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 4 (9) , 733-738
- https://doi.org/10.1038/nrm1197
Abstract
Five years ago, Epac — a guanine nucleotide exchange factor for the Ras-like small GTPases Rap1 and Rap2 — was found to be a new target of cyclic AMP, which opened up new avenues for cAMP research. Structural analysis of the cAMP-binding domains of Epac2 has identified a unifying mechanism for how cAMP activates proteins, and the design and synthesis of an Epac-specific cAMP analogue has paved the way for future discoveries.Keywords
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