Profiles of Endogenous Prostaglandin F2α, Thromboxane A2 and Prostacyclin with regard to Cardiovascular and Organ Functions in Early Septic Shock in Man

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Abstract
15 out of 68 patients with severe sepsis were examined in an early stage of shock and analyzed for objective hemodynamic and functional shock criteria. These data were correlated to endogenous plasma concentrations of the vasoactive arachidonate derivatives: prostaglandin F2α (PGF2α), thromboxane A2 (TXA2) and prostacyclin (PGI2). Marked differences in invasively measured data of cardiac, pulmonary and renal functions divided clinically otherwise comparable patients into group I and II. Group I was characterized by a hypodynamic response as compared to group II which was hyperdynamic. In spite of similar levels of PGF2α (570 ± 80 vs. 560 ± 103 pg/ml) in both groups indicating a comparable state of arachidonate turnover, opposing profiles with regard to the TXA2/PGI2 ratio as measured from their stable degradation products were found (TXB2 [I]: a740 ± 184; TXB2 [II]: 280 ± 75; 6-k-PGF1α [I]: 260 ± 117; 6-k-PGF1α [II]: 940 ± 190 pg/ml). It is concluded that early sepsis in man leads to variable profiles of endogenously released prostaglandins and thromboxane in which the predominance of PGI2 over TXA2 is associated with better cardiovascular performance and organ functions, and vice versa.