Differences in Efficiency of Energy Transfer in Mitochondrial Systems Derived from Normal and Failing Hearts.

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Abstract
A method for producing congestive heart failure in animals has recently become available and has afforded the opportunity to study one important type of congestive heart failure, i.e., decreased output failure, backward failure, or increased forward resistance failure, etc., with employment of biochemical technics. QNO2 values were 1170 and 1032 for the normal guinea pig hearts and experimental guinea pig mitochondrial systems for a -ketoglutarate oxidation respectively. P/O ratios were 2.95 and 2.91 respectively. Additional of cofactors (CoA, DPN and TPN), increased QNO2 values from 1170 to 1480 in the normal heart mitochondrial systems and from 1032 to 1524 in the mitochondrial systems derived from animals in experimental congestive heart failure. P/O ratios decreased slightly in the normal system (2.95 and 2.32) while the P/O ratio decreased from 2.91 to 1.95 in the animals in congestive heart failure. Although the efficiency of phosphorylation in the mitochondrial system derived from failing hearts is markedly decreased during the influence of the cofactors, energy production is maintained by the inordinate increase in respiration.

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