Extracellular Cyclic AMP-Phosphodiesterase Accelerates Differentiation in Dictyostelium discoideum
- 1 February 1976
- journal article
- research article
- Published by Microbiology Society in Journal of General Microbiology
- Vol. 92 (2) , 351-368
- https://doi.org/10.1099/00221287-92-2-351
Abstract
Extracellular cyclic AMP-phosphodiesterase accelerates the development of aggregation competence in D. discoideum when present during the preaggregation stage. The effect on development appears to depend only on hydrolysis of extracellular cyclic AMP and not on other properties of the phosphodiesterase molecule. Extracellular cyclic AMP-phosphodiesterase, as a promoter of differentiation, acts mainly throughout the 1st half of interphase. Apparently cyclic AMP oscillations control the rate and possibly the initiation of development. Since extracellular cyclic AMP-phosphodiesterase acts from the beginning of interphase, cyclic AMP oscillations may also occur from early interphase, at least in the presence of this enzyme. Probably the cyclic AMP oscillator is a determinant, but not a product, of the developmental program.Keywords
This publication has 4 references indexed in Scilit:
- Properties of Cyclic 3',5'-Nucleotide Phosphodiesterase from Rat Brain*Biochemistry, 1967
- A NEW APPROACH TO THE PROBLEM OF AGGREGATION IN THE CELLULAR SLIME MOLDSThe Biological Bulletin, 1966
- DISC ELECTROPHORESIS – II METHOD AND APPLICATION TO HUMAN SERUM PROTEINS*Annals of the New York Academy of Sciences, 1964
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951