Certain clinical manifestations of erythroblastosis fetalis in live born infants have been studied in relation to outcome. The likelihood of recovery is inversely related to the degree of anemia and hepatosplenomegaly present at birth, but kernicterus, which is the chief threat to eventual complete recovery, bears no close relation to these signs. Serologic studies in newborn infants with erythroblastosis fetalis have been generally of little value in establishing a prognosis. Male infants appear to have a more severe illness and a worse prognosis than female infants. Jaundice of the skin and scleras has not been found at the time of birth in any baby with erythroblastosis fetalis.