The effect in post-menopausal women of natural human and artificial oestrogens on the concentration in serum of prolactin

Publisher Website
Google Scholar
Abstract
Women (25) aged 53-78 yr with at least 2 yr menopause were divided in 3 groups receiving 1 of the following oral treatments for 3 wk: 2 mg estradiol-17.beta. plus 1 mg estriol, 4 mg estradiol-17.beta. plus 2 mg estriol or 50 .mu.g ethinylestradiol daily. Blood samples were collected before, during and after the treatment and the effect on the serum concentration of prolactin, estradiol-17.beta., follicle-stimulating hormone [follitropin] and luteinizing hormone lutropin was evaluated. During treatment with natural human estrogens serum estradiol-17.beta. levels were significantly higher than before treatment. The serum concentration of prolactin was unchanged in patients receiving 2 mg estradiol-17.beta. plus 1 mg estriol but increased in patients receiving 4 mg estradiol-17.beta. plus 2 mg estriol or 50 .mu.g ethinylestradiol, thus indicating dose-dependence for natural human estrogens. The increase was moderate, and these higher levels were not significantly different from levels of prolactin in serum found in 16 younger women. Concentrations of follicle-stimulating hormone and luteinizing hormone were depressed during treatment, the former to significantly lower levels when higher doses of estrogens were used.

This publication has 1 reference indexed in Scilit: