An interaction of β‐amyloid with aluminium in vitro
- 21 June 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 324 (3) , 293-295
- https://doi.org/10.1016/0014-5793(93)80137-j
Abstract
We have used circular dichroism spectroscopy to confirm that, in a membrane‐mimicking solvent, AβP(1–40) adopts a partially helical conformation and we have demonstrated the loss of this structure in the presence of physiologically relevant concentrations of aluminium. This is the first evidence of a direct biochemical interaction between aluminium and β‐amyloid and may have important implications for the pathogenesis of Alzheimer's disease.Keywords
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