Stimulation of RNA Synthesis in L-929 Cells by Rabbit Tumor Necrosis Factor
- 1 March 1979
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 160 (3) , 354-358
- https://doi.org/10.3181/00379727-160-40449
Abstract
BCG or Corynebacterium parvum [Propionibacterium acnes] primed rabbits injected with [Salmonella typhimurium] endotoxin contained a serum substance called tumor necrosis factor (TNF) that killed transformed mouse L-929 cells but not secondary normal mouse embryo fibroblasts. L-929 cells treated with TNF showed a 6-fold stimulation of RNA synthesis that reached a maximum at approximately the same time as they started to die. Non-sensitive normal mouse embryo fibroblasts as well as TNF resistant L-929 cells did not show this large stimulation of RNA synthesis. When actinomycin D was employed to inhibit RNA synthesis, in the presence of TNF, a synergistic effect on killing of the transformed cells occurred.This publication has 1 reference indexed in Scilit:
- Vitamin A-Induced Density-Dependent Inhibition of L-Cell Proliferation2JNCI Journal of the National Cancer Institute, 1977