FTY720, a Synthetic Sphingosine 1 Phosphate Analogue, Inhibits Development of Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice
Top Cited Papers
- 30 January 2007
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 115 (4) , 501-508
- https://doi.org/10.1161/circulationaha.106.641407
Abstract
Background— Numerous in vitro studies suggest that sphingosine 1-phosphate (S1P), a bioactive lysosphingolipid associated with high-density lipoproteins, accounts at least partly for the potent ant...Keywords
This publication has 46 references indexed in Scilit:
- Type 4 sphingosine 1‐phosphate G protein‐coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migrationThe FASEB Journal, 2005
- Sphingosine 1-phosphate and its receptors: an autocrine and paracrine networkNature Reviews Immunology, 2005
- Low-Dose FK506 Blocks Collar-Induced Atherosclerotic Plaque Development and Stabilizes Plaques in ApoE-/- MiceAmerican Journal of Transplantation, 2005
- Sphingosine-1-Phosphate Prevents Tumor Necrosis Factor-α–Mediated Monocyte Adhesion to Aortic Endothelium in MiceArteriosclerosis, Thrombosis, and Vascular Biology, 2005
- Immunomodulator FTY720 Induces eNOS-Dependent Arterial Vasodilatation via the Lysophospholipid Receptor S1P 3Circulation Research, 2005
- Physiological sphingosine 1‐phosphate requirement for optimal activity of mouse CD4+25+regulatory T CellsThe FASEB Journal, 2004
- Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I studyTransplantation, 2003
- Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferationBlood, 2003
- Sphingosine-1-phosphate: an enigmatic signalling lipidNature Reviews Molecular Cell Biology, 2003
- The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate ReceptorsJournal of Biological Chemistry, 2002