Cilofungin (LY121019) inhibits Candida albicans (1-3)-beta-D-glucan synthase activity
Open Access
- 1 December 1988
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 32 (12) , 1901-1903
- https://doi.org/10.1128/aac.32.12.1901
Abstract
Cilofungin (LY121019) inhibited Candida albicans growth and activity of (1-3)-beta-glucan synthase, for which it was a noncompetitive inhibitor with a Ki-app of 2.5 microM. Cilofungin had no effect on chitin synthase activity. Based on these and other data, it seems likely that cilofungin inhibits fungal growth by inhibiting (1-3)-beta-glucan synthase activity.This publication has 9 references indexed in Scilit:
- LY121019 inhibits Neurospora crassa growth and (1-3)-.BETA.-D-glucan synthase.The Journal of Antibiotics, 1988
- Optimal conditions for the release of protoplasts ofNeurospora using Novozym 234Experimental Mycology, 1987
- Changes in the Plasma Membrane of Regenerating Protoplasts of Candida albicans as Revealed by Freeze-fracture Electron MicroscopyMicrobiology, 1986
- In vitro and in vivo anti-Candida activity and toxicology of LY121019.The Journal of Antibiotics, 1984
- (1,3)‐β‐d‐Glucan Synthase from Budding and Filamentous Cultures of the Dimorphic Fungus Candida albicansEuropean Journal of Biochemistry, 1982
- Chitin synthase activity from the Slime variant of Neurospora crassaBiochimica et Biophysica Acta (BBA) - Enzymology, 1979
- A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry, 1976
- The kinetics of enzyme-catalyzed reactions with two or more substrates or products☆I. Nomenclature and rate equationsBiochimica et Biophysica Acta, 1963