High Angiotensin Converting Enzyme (Kininase II) Activity in the Cerebrospinal Fluid of Spontaneously Hypertensive Adult Rats

1 June 1987

journal article
Published by Wolters Kluwer Health in Journal Of Hypertension

Vol. 5 (3) , 355-357
https://doi.org/10.1097/00004872-198706000-00015

Abstract

Angiotensin converting enzyme (ACE, Kininase II, E.C. 3.4.15.1) activity was measured in the cerebrospinal fluid of 4- and 16-week-old spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) normotensive controls. Adult SHR showed higher cerebrospinal fluid enzyme activity than normotensive age-matched WKY (19.6 ± 1 and 32.3 ± 5 nmol/h per ml in WKY and SHR, respectively, P<0.025). Conversely, there were no significant differences in enzyme activity in the cerebrospinal fluid of young animals. Our results support the hypothesis of enhanced activity of the central angiotensin system during the established phase of spontaneous hypertension in rats.

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