Influence of ipratropiumbromide on heart rate and hemodynamics in patients with sinus bradycardia

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Abstract
In 13 patients with sinus bradycardia, heart rate and hemodynamics were recorded before and 3, 30, 60, and 120 minutes following intravenous administration of 0.5 mg ipratropiumbromide (Itrop® by C. H. Boehringer Sohn, Ingelheim, West Germany). Heart rate already started to rise during the injection of ipratropiumbromide. It increased by an average of 78% three minutes following the administration as compared to pretreatment control values. Mean heart rate still was markedly increased by an average of 26% at 120 min following the injection of the drug. This effect of ipratropiumbromide on heart rate was accompanied by an increase in cardiac index while stroke volume decreased due to a decrease in ejection fraction and diastolic filling time.

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