Immunotherapy of Respiratory Syncytial Virus Infection in Cotton Rats (Sigmodon fulviventer) Using IgG in a Small-Particle Aerosol
- 1 December 1992
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 166 (6) , 1422-1424
- https://doi.org/10.1093/infdis/166.6.1422
Abstract
To determine whether aerosolized IgG can be used effectively in the treatment of respiratory syncytial virus (RSV) infections, cotton rats were infected intranasally with RSV and treated 3 days later with human IgG containing anti-RSV antibodies delivered in a small-particle aerosol. Pulmonary histology and virus titers were determined 24 h after IgG treatment. A single IS-min exposure to aerosolized IgG did not exacerbate pulmonary pathology and effected a SO-fold reduction in pulmonary virus titer (2.95 vs. 4.67 log10 ogeometric mean pfu/g for untreated controls, P < .001), which was comparable to that effectedby intranasally instilled IgG (50 mg/kg) (3.24 vs. 4.67 l0glO geometric mean pfu/g for controls, P < .001). A 15-min exposure to aerosolized ribavirin (20 mg/ml.) was not effective in reducing pulmonary virus. This study suggests that aerosolized IgG could be useful in the treatment of RSV lower respiratory tract infections and that it compares favorably with ribavirin.Keywords
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