Threatened Abortion Studied by Estradiol-17β in Serum and Ultrasound

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Abstract
Women (100) were admitted to the hospital between 7 and 18 wk gestation because of vaginal bleeding and threatened abortion. Serum concentration of estradiol-17.beta. was determined by radioimmunoassay. Ultrasound examination using a gray-scale scanner was performed. The values for prediction of abortion or successful outcome of pregnancy were calculated for estradiol (E2) and ultrasound separately and in combination. Prediction of abortion from a low E2 concentration combined with an ultrasound examination showing no fetal life was totally reliable. Prediction of successful outcome of pregnancy from a normal E2 or an ultrasound examination showing fetal life, or both, was 79.5% reliable. If no signs of fetal life were found by ultrasound examination from 10 wk gestation on, the pregnancy was doomed. Before this gestational age, measurements of E2 in serum gave supplementary information concerning the outcome of the threatened pregnancy.

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