Requirement of a 12-Base-Pair TATT-Containing Sequence and Viral Lytic DNA Replication in Activation of the Kaposi's Sarcoma-Associated Herpesvirus K8.1 Late Promoter
- 1 March 2004
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 78 (5) , 2609-2614
- https://doi.org/10.1128/jvi.78.5.2609-2614.2004
Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV) K8.1 late promoter consists of a minimal 24-bp sequence, with a TATA-like, 12-bp promoter core, AATATTAAAGGG, and is active on a reporter only in butyrate-induced KSHV-infected cells. The activity of the K8.1 promoter can be enhanced (>15-fold) by the KSHV left-end lytic origin of DNA replication (oriLyt-L) sequence while providing inefficient replication of plasmid DNA and is inhibited by viral DNA replication inhibitors, suggesting that activation of the K8.1 promoter on the reporter is involved in KSHV lytic DNA replication largely by trans .Keywords
This publication has 25 references indexed in Scilit:
- Kaposi's Sarcoma-Associated Herpesvirus Lytic Origin ( ori-Lyt )-Dependent DNA Replication: Identification of the ori-Lyt and Association of K8 bZip Protein with the OriginJournal of Virology, 2003
- Split genes and their expression in Kaposi's sarcoma‐associated herpesvirusReviews in Medical Virology, 2003
- Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Contains Two Functional Lytic Origins of DNA ReplicationJournal of Virology, 2002
- Cell Type-Specific Replication of Simian Virus 40 Conferred by Hormone Response Elements in the Late PromoterJournal of Virology, 2002
- Kaposi's Sarcoma-associated Herpesvirus K8 Exon 3 Contains Three 5′-Splice Sites and Harbors a K8.1 Transcription Start SiteJournal of Biological Chemistry, 2002
- The Initiator Element in a Herpes Simplex Virus Type 1 Late-Gene Promoter Enhances Activation by ICP4, Resulting in Abundant Late-Gene ExpressionJournal of Virology, 2002
- Identification of Herpesvirus-Like DNA Sequences in AIDS-Sssociated Kaposi's SarcomaScience, 1994
- Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genesCell, 1994
- A specific 15-bp TATA box promoter element is required for expression of a herpes simplex virus type 1 late gene.Genes & Development, 1988
- Site-specific base substitution and deletion mutations that enhance or suppress transcription of the SV40 major late RNACell, 1982