Detection of Varicella-Zoster Virus-Specific IgA Antibodies in Varicella and Zoster Patients and in Healthy Adults of Various Ages by Solid-Phase Radioimmunoassay

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Abstract
The varicella-zoster virus(VZV)-specific serum A IgA response was studied in varicella and zoster patients and in healthy adults of various ages by a sensitive solid-phase radioimmunoassay technique. Significant rises in VZV-specific IgA titer were found for both varicella and zoster patients, while VZV-specific IgA was also detected in > 90% of healthy adults but at lower titers. No significant decrease in VZV-specific IgA titer with increasing age was found. The role of humoral vs. cell-mediated immunity in VZV reactivation is discussed.