THE RELATIONSHIP OF COPPER TO HEMATOPOIESIS IN EXPERIMENTAL HEMORRHAGIC ANEMIA

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Abstract
Young growing dogs on a raw milk diet supplemented with crystalline B vits. and Mn were rendered anemic by bleeding. Blood analysis showed a characteristic picture of secondary anemia. The anemia showed no response to dietary supplementation of Fe in the absence of copper. The daily adm. of 3 mg. Cu brought about an immediate and rapid increase in Hb hematocrit and red cell counts to normal values. An Fe deficiency in the presence of adequate (3 mg.) Cu caused a nutritional anemia and a concomitant decrease in mean corpuscular volume. The adm. of 10, 20 or 30 mg. Fe with 3 mg. Cu gave the characteristic remission in the anemic dogs.

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