METABOLIC-ACTIVATION OF 1,2-DIBROMOETHANE BY GLUTATHIONE TRANSFERASE AND BY MICROSOMAL MIXED-FUNCTION OXIDASE - FURTHER EVIDENCE FOR FORMATION OF 2 REACTIVE METABOLITES
- 1 January 1981
- journal article
- research article
- Vol. 33 (3) , 449-461
Abstract
In rat liver cytosolic preparations containing added glutathione, radioactivity from [14C] 1,2-dibromoethane became bound preferentially to added polycytidylic acid. When microsomes and NADPH were present, the radioactivity became bound selectively to microsomal proteins.This publication has 3 references indexed in Scilit:
- Binding of Carcinogenic Halogenated Hydrocarbons to Cell Macromolecules2JNCI Journal of the National Cancer Institute, 1979
- Effects of ethylene dibromide on reproduction in male and female ratsToxicology and Applied Pharmacology, 1979
- Repair of rat liver DNA in vivo damaged by ethylene dibromideBiochemical Pharmacology, 1977