Coumarin 7-Hydroxylase in Inbred Strains of Mice: Comparison with Other Microsomal Monooxygenase Activities and Induction by Pyrazole

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Abstract
This study was carried out in order to find out the effects of pyrazole on liver drug metabolism in several inbred mice: D2, B6, BALB, and AKR and in the outbred mouse NMRI. Compared to control pyrazole treatment decreased the microsomal cytochrome P-450 content of liver to 60–70% and benzo(a)pyrene hydroxylase and ethylmorphine N-demethylase activities to 40–55% and increased 7-ethoxycoumarin 0-deethylase activity to 100–200% in AKR, BALB, B6, and NMRI mice and 300% in D2 mouse. Coumarin 7hydroxylase was increased only 200–300% in B6, AKR, and BALB mice and as much as 700% in D2 and 900% in NMRI mice compared to control. Coumarin 7-hydroxylase is under different genetic control from other monooxygenase activities and differently expressed in various strains of mice.