Absence of Epstein-Barr virus carrying cells in synovial membranes and subcutaneous nodules of patients with rheumatoid arthritis.
Open Access
- 1 August 1993
- journal article
- research article
- Published by Elsevier in Annals of the Rheumatic Diseases
- Vol. 52 (8) , 608-609
- https://doi.org/10.1136/ard.52.8.608
Abstract
OBJECTIVES--To determine whether the Epstein-Barr virus is present in synovial membranes and subcutaneous nodules of patients with rheumatoid arthritis. METHODS--A sensitive in situ hybridisation technique was applied to tissue sections of 11 synovial membranes and five rheumatoid nodules. RESULTS--Cells carrying the Epstein-Barr virus were not detected using EBER and BHLF1 oligonucleotides in the tissue samples investigated here. CONCLUSIONS--Although it has been suggested that the Epstein-Barr virus could play a part in the aetiology of rheumatoid arthritis, it was not detected in synovial membranes and subcutaneous lesions in this study.Keywords
This publication has 15 references indexed in Scilit:
- Expression of Epstein–Barr Virus–Encoded Small RNA (by the EBER-1 Gene) in Liver Specimens from Transplant Recipients with Post-Transplantation Lymphoproliferative DiseaseNew England Journal of Medicine, 1992
- Detection of Epstein-Barr virus DNA by in Situ hybridization and polymerase chain reaction in salivary gland biopsy specimens from patients with Sjögren's syndromeThe American Journal of Medicine, 1991
- Susceptibility to rheumatoid arthritis maps to a T-cell epitope shared by the HLA-Dw4 DR beta-1 chain and the Epstein-Barr virus glycoprotein gp110.Proceedings of the National Academy of Sciences, 1989
- Epstein-Barr virus infection and autoimmunity in rheumatoid arthritis.Annals of the Rheumatic Diseases, 1988
- The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisArthritis & Rheumatism, 1988
- Abnormally elevated frequency of Epstein-Barr virus-infected B cells in the blood of patients with rheumatoid arthritis.Journal of Clinical Investigation, 1984
- Rheumatoid Arthritis Nuclear Antigen and Epstein‐Barr VirusArthritis & Rheumatism, 1984
- Antibodies to the Epstein-Barr virus nuclear antigen and to rheumatoid arthritis nuclear antigen identify the same polypeptide.Proceedings of the National Academy of Sciences, 1983
- Elevated Levels of Antibodies to Epstein-Barr Virus Antigens in Sera and Synovial Fluids of Patients with Rheumatoid ArthritisJournal of Clinical Investigation, 1981
- Seroepidemiological study of relationships between Epstein-Barr virus and rheumatoid arthritis.Journal of Clinical Investigation, 1981