ABSORPTION, DISTRIBUTION AND EXCRETION OF PHOTOMIREX IN THE RAT
- 1 January 1979
- journal article
- research article
- Vol. 7 (1) , 24-27
Abstract
The absorption, distribution and excretion of the insecticide photomirex were investigated in the rat. Photomirex was absorbed slowly after oral administration, appeared in the blood at 1.5 h and reached the peak concentration 4 h after dosing. Elimination from the blood was studied in rats receiving single i.v. doses; the semilog decay curve was triphasic. The highest concentrations were present in the fat, liver and skin. Approximately 38-42% of the orally dosed photomirex was excreted in the feces in the first 3 days and 51-55% was eliminated in 28 days. Only trace amounts of photomirex were found in the urine (< 0.09% of the total dose in 24 h). Photomirex constituted about 95% of the total radioactivity found in the tissues and feces. No metabolite was detected in the radioactive material extracted from tissues or feces.This publication has 3 references indexed in Scilit:
- Photomirex: synthesis and assessment of acute toxicity, tissue distribution, and mutagenicityJournal of Agricultural and Food Chemistry, 1978
- Pharmacokinetics of mirex in goats. 1. Effect on reproduction and lactationJournal of Agricultural and Food Chemistry, 1977
- Mass spectral confirmation and analysis by the Hall detector of mirex and photomirex in Herring Gulls from Lake OntarioJournal of Agricultural and Food Chemistry, 1976