The Effect of Testicular X‐irradiation on Spermatogenesis in Man

12 November 1983

journal article
research article
Published by Wiley in Journal of Andrology

Vol. 4 (6) , 387-392
https://doi.org/10.1002/j.1939-4640.1983.tb00765.x

Abstract

Existing data concerning the effects of x-irradiation on spermatogenesis in man were analyzed and the results were compared to published data on the mouse. Testicular x-irradiation produced a transient, but substantial, suppression of sperm counts in man, with an ED₅₀ near 11 rad. The length of time to recovery was proportional to the irradiation dose. The ED₅₀ for suppression of type A spermatogonia following radiation exposure in man was similar (9.7 rad), although the response curves for spermatogonia and sperm count were not parallel. The effect of irradiation on type A spermatogonia in the mouse was parallel to that found in man, but with an ED₅₀ of 30.0 rad. These results suggest that, compared to the mouse, spermatogenesis in man is approximately 3.1 times more sensitive to ionizing irradiation.

Keywords

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