A CYTOGENETIC STUDY OF REPEATED SPONTANEOUS-ABORTIONS

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 32  (5) , 723-730
Abstract
During a cytogenetic study of spontaneous abortions, successive abortions from 40 couples were karyotyped. The chromosome constitutions of the 1st and 2nd abortions were highly correlated. In each of 21 instances in which the 1st abortion was chromosomally normal, the subsequent abortion(s) was normal as well. In 9 cases, the 2 abortions were chromosomally abnormal, and in 4 of these, both abortions were trisomic. Findings from other studies of consecutive spontaneous abortions together with present data suggested that certain couples are at an increased risk for repeated chromosomally normal abortion or for repeated trisomic conceptions. The increased risk of trisomy does not seem to be restricted to a particular chromosome, and the magnitude of the risk increase appears to be independent of maternal age.