Detecting Ancient Admixture and Estimating Demographic Parameters in Multiple Human Populations
Open Access
- 6 May 2009
- journal article
- Published by Oxford University Press (OUP) in Molecular Biology and Evolution
- Vol. 26 (8) , 1823-1827
- https://doi.org/10.1093/molbev/msp096
Abstract
We analyze patterns of genetic variation in extant human polymorphism data from the National Institute of Environmental Health Sciences single nucleotide polymorphism project to estimate human demographic parameters. We update our previous work by considering a larger data set (more genes and more populations) and by explicitly estimating the amount of putative admixture between modern humans and archaic human groups (e.g., Neandertals, Homo erectus, and Homo floresiensis). We find evidence for this ancient admixture in European, East Asian, and West African samples, suggesting that admixture between diverged hominin groups may be a general feature of recent human evolution.Keywords
This publication has 43 references indexed in Scilit:
- Methods for Human Demographic Inference Using Haplotype Patterns From Genomewide Single-Nucleotide Polymorphism DataGenetics, 2009
- A Complete Neandertal Mitochondrial Genome Sequence Determined by High-Throughput SequencingCell, 2008
- A novel DNA sequence database for analyzing human demographic historyGenome Research, 2008
- The Timing of Selection at the Human FOXP2 GeneMolecular Biology and Evolution, 2008
- Inconsistencies in Neanderthal Genomic DNA SequencesPLoS Genetics, 2007
- Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in EuropeansNature Genetics, 2007
- Sequencing and Analysis of Neanderthal Genomic DNAScience, 2006
- Possible Ancestral Structure in Human PopulationsPLoS Genetics, 2006
- Maximum-Likelihood Estimation of Demographic Parameters Using the Frequency Spectrum of Unlinked Single-Nucleotide PolymorphismsGenetics, 2004
- No Evidence of Neandertal mtDNA Contribution to Early Modern HumansPLoS Biology, 2004