Effects of Concanavalin A on the isolated perfused rat liver
- 1 January 1975
- journal article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 289 (2) , 205-215
- https://doi.org/10.1007/bf00501306
Abstract
In the isolated perfused liver, Concanavalin A provoked a significant decrease of flow rate within 2 to 4 min which was dose-dependent and could be partly inhibited by specific antagonists. Furthermore it was found that the lectin led to a decline of the respiration, an increase of the lactate/pyruvate ratio and a release of the transaminases into the medium. It was suggested that Concanavalin A displaced endothelial cells in the liver capillaries, which occluded the vessels and decreased the flow rate. The decreased respiration was considered to be secondary to this effect.Keywords
This publication has 16 references indexed in Scilit:
- Concanavalin a binding by isolated plasma membranes and endomembranes from liver and mammary glandFEBS Letters, 1974
- Binding of concanavalin A‐sepharose to glycoproteins of liver microsomal membranesFEBS Letters, 1974
- The microcirculatory hepatic unitMicrovascular Research, 1973
- Studies on the in vitro effects of insulin on glycogen synthesis and ultra-structure in isolated rat liver hepatocytesBiochemical and Biophysical Research Communications, 1973
- Effect of metabolic inhibitors on the agglutination of tumor cells by concanavalin a and Ricinus communis agglutininBiochemical and Biophysical Research Communications, 1973
- On the presence of a Concanavalin-A reactive coat over the endothelial aortic surface and its modifications during early experimental cholesterol atherogenesis in rabbitsVirchows Archiv, 1973
- The effect of perfusate pH on respiration and glycolysis in the isolated rat liver perfused with an erythrocyte- and protein-free mediumBiochimica et Biophysica Acta (BBA) - General Subjects, 1972
- Embryonic and Neoplastic Cell Surfaces: Availability of Receptors for Concanavalin A and Wheat Germ AgglutininScience, 1971
- Untersuchungen zum Wirkungsmechanismus des PhalloidinsNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1967
- THE DOMINANT ROLE OF THE LIVER IN PLASMA PROTEIN SYNTHESISThe Journal of Experimental Medicine, 1951