Oligodendrogenesis is differentially regulated in gray and white matter of jimpy mice
- 7 November 2002
- journal article
- research article
- Published by Wiley in Journal of Neuroscience Research
- Vol. 70 (5) , 645-654
- https://doi.org/10.1002/jnr.10418
Abstract
The factors that regulate oligodendrogenesis have been studied extensively in optic nerve, where oligodendrocyte production and myelination quickly follow colonization of the nerve by progenitor cells. In contrast, oligodendrocyte production in the cerebral cortex begins approximately 1 week after progenitor cell colonization and continues for 3–4 weeks. This and other observations raise the possibility that oligodendrogenesis is regulated by different mechanisms in white and gray matter. The present study examined oligodendrocyte production in the developing cerebral cortex of jimpy (jp) and jimpymsd (msd) mice, which exhibit hypomyelination and oligodendrocyte death due to mutations in and toxic accumulations of proteolipid protein, the major structural protein of CNS myelin. Proliferation of oligodendrocyte progenitors and production of myelinating oligodendrocytes was reduced in jp cerebral cortex when compared to wild‐type (wt) and msd mice. The incidence of oligodendrocyte cell death was similar in jp and msd cortex, but total dying oligodendrocytes were greater in msd. We confirm previous reports of increased oligodendrocyte production in white matter of both jp and msd mice. The jp mutation, therefore, reduces oligodendrocyte production in cerebral cortex but not in white matter. These data provide additional evidence that oligodendrogenesis is differentially regulated in white matter and gray matter and implicate PLP/DM20 as a modulator of these differences.Keywords
This publication has 56 references indexed in Scilit:
- Impairment of the Ubiquitin-Proteasome System by Protein AggregationScience, 2001
- Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampusNature, 2000
- Disrupted Proteolipid Protein Trafficking Results in Oligodendrocyte Apoptosis in an Animal Model of Pelizaeus-Merzbacher DiseaseThe Journal of cell biology, 1998
- Altered Trafficking of Mutant Connexin32Journal of Neuroscience, 1997
- Expression of the APC tumor suppressor protein in oligodendrogliaGlia, 1996
- Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice.Proceedings of the National Academy of Sciences, 1994
- Many naturally occurring mutations of myelin proteolipid protein impair its intracellular transportJournal of Neuroscience Research, 1994
- Cell death and control of cell survival in the oligodendrocyte lineagePublished by Elsevier ,1992
- Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd miceJournal of Neuroscience, 1990
- Expression of galactocerebroside in developing normal and jimpy oligodendrocytesin situJournal of Neurocytology, 1988