The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer
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Open Access
- 15 January 2008
- journal article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 68 (2) , 537-544
- https://doi.org/10.1158/0008-5472.can-07-5682
Abstract
Cannabinoids are a class of pharmacologic compounds that offer potential applications as antitumor drugs, based on the ability of some members of this class to limit inflammation, cell proliferation, and cell survival. In particular, emerging evidence suggests that agonists of cannabinoid receptors expressed by tumor cells may offer a novel strategy to treat cancer. Here, we review recent work that raises interest in the development and exploration of potent, nontoxic, and nonhabit forming cannabinoids for cancer therapy. [Cancer Res 2008;68(2):339–42]Keywords
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- Mesenchyme Forkhead 1 ( FOXC2 ) plays a key role in metastasis and is associated with aggressive basal-like breast cancersProceedings of the National Academy of Sciences, 2007
- Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?Nature Reviews Cancer, 2007
- The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarityOncogene, 2007
- The Spemann organizer gene, Goosecoid , promotes tumor metastasisProceedings of the National Academy of Sciences, 2006
- Invasion and Metastasis in Colorectal Cancer: Epithelial-Mesenchymal Transition, Mesenchymal-Epithelial Transition, Stem Cells and β-CateninCells Tissues Organs, 2005
- Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor MetastasisCell, 2004
- MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cellsThe Journal of cell biology, 2002
- The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membraneNature Cell Biology, 2002
- The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expressionNature Cell Biology, 2000
- The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cellsNature Cell Biology, 2000