Responses to captopril and hydrochlorothiazide in black patients with hypertension

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Abstract
The effects of captopril (C) in doses of up to 450 mg/day, placebo (P) and hydrochlorothiazide (H) in doses of 50-100 mg/day were compared in double-blind studies in 38 black patients. Mean blood pressure response to C was only slightly greater than to P (systolic response difference only). Mean blood pressure responses to H were greater than to C. Results were compared to available data on 185 white and black patients treated similarly. In white patients, response to C was greater than to P, but response to H was approximately equal to that of C. In black patients, the systolic response to C was greater than that to P and the response to H was greater than that to C. Apparently, black and white patients differ in response to certain antihypertensive drugs.