Molecular conformation of sodium heparan sulphate in the condensed phase
- 1 March 1977
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 161 (3) , 495-498
- https://doi.org/10.1042/bj1610495
Abstract
By using the X-ray-diffraction results reported previously for sodium heparan sulfate, a 2-fold helical conformation with an axially projected disaccharide repeat (h) equal to 0.93 nm was examined in detail. On the basis of a repeating sequence of 1,4-.alpha.-D-glucosamine and 1,4-.beta.-D-glucuronic acid, trial and stereochemically feasible molecular models were computer-generated. An optimum 2-fold helical conformation is proposed, incorporating stabilizing intra-chain H-bonds across both glycosidic linkages.This publication has 14 references indexed in Scilit:
- Hyaluronic acid: Structure of a fully extended 3-fold helical sodium salt and comparison with the less extended 4-fold helical formsPublished by Elsevier ,2006
- The Effect of Calcium on the Macromolecular Properties of Heparan SulfateConnective Tissue Research, 1975
- The disaccharide repeating-units of heparan sulfateCarbohydrate Research, 1974
- High molecular-weight heparan sulfate from the cell surfaceBiochemical and Biophysical Research Communications, 1974
- Distribution of sulphate and iduronic acid residues in heparin and heparan sulphateBiochemical Journal, 1974
- X-ray diffraction patterns from chondroitin 4-sulphate, dermatan sulphate and heparan sulphate (Short Communication)Biochemical Journal, 1973
- Heparan sulfates of cultured cells. II. Acid-soluble and -precipitable species of different cell linesBiochemistry, 1971
- Heparan sulfates of cultured cells. I. Membrane-associated and cell-sap species in Chinese hamster cellsBiochemistry, 1971
- Production of Heparin Related Mucopolysaccharides by Mammalian Cells in CultureExperimental Biology and Medicine, 1970
- Evidence for the existence of a multichain proteoglycan of heparan sulphateBiochemical Journal, 1970