Conformational properties of amphotericin B amide derivatives – impact on selective toxicity
- 1 January 2000
- journal article
- Published by Springer Nature in Journal of Computer-Aided Molecular Design
- Vol. 14 (7) , 689-703
- https://doi.org/10.1023/a:1008144208706
Abstract
Even though it is highly toxic, Amphotericin B (AmB), an amphipathic polyene macrolide antibiotic, is used in the treatment of severe systemic fungal infections as a life-saving drug. To examine the...Keywords
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