Studies on the Role of Ca++ and Mg++ in Complement Fixation and Immune Hemolysis
Open Access
- 1 November 1953
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 71 (5) , 367-373
- https://doi.org/10.4049/jimmunol.71.5.367
Abstract
Summary: The role of Ca++ in C′ fixation has been studied by two methods: 1) With a system depleted of divalent cations by passage through a resin, Ca++, but not Mg++, caused a marked enhancement in C′ fixation; 2) With a system containing EDTA as an inhibitory chelating agent, Ca++, but not Mg++, Sr++, or Ba++, restores C′ fixation. Therefore Ca++ is specifically required in C′ fixation.Keywords
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