Hypoxia‐Induced Neurotransmitter Deficits in Neonatal Rats Are Partially Corrected by Exogenous GM1 Ganglioside
- 1 September 1990
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 55 (3) , 864-869
- https://doi.org/10.1111/j.1471-4159.1990.tb04571.x
Abstract
Exposure of 7-day-old rats to 7% oxygen/balance nitrogen for 2 h results in selective changes of cholinergic, serotonergic, and dopaminergic neuronal markers in the frontal cortex, hippocampus, and striatum when evaluated 3 weeks after the insult. There is also about a 15% deficiency in brain weight. Treatment with GM1 ganglioside, 50 mg/kg i.p., for 2 days before and for 3 weeks after the hypoxic insult partially corrects the neurodevelopmental abnormalities including the deficiency in brain weight. We conclude that GM1 ganglioside might have therapeutic potential for treating suspected neonatal hypoxia.Keywords
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