Thymus‐independent induction of idiotype suppression in newborn mice by syngeneic anti‐idiotype antisera
- 1 January 1985
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 15 (6) , 580-586
- https://doi.org/10.1002/eji.1830150610
Abstract
BALB/c and BALB/c nu/nu mice were shown to express to a variable extent in their response against dextran B1355S (Dex), an idiotype which is present on the Dex-reactive BALB/c myeloma protein MOPC104E. Injection of minute amounts of syngeneic anti-MOPC 104E idiotype antisera into neonatal euthymic or athymic BALB/c mice suppressed this idiotype in the Dex-specific response of the adult animals. When spleen cells from suppressed BALB/c mice were transferred into irradi- ated BALB Ighb mice the state of suppression persisted. Data are discussed with respect to possible mechanisms regulating expression of this idiotype.This publication has 35 references indexed in Scilit:
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