Activation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in homogenates of developing rat brain

Publisher Website
Google Scholar
Abstract
The specific activity of 3-hydroxy-3-methylglutaryl-CoA reductase (EC 1.1.1.34) increases when homogenates of developing rat brain are incubated at 37.degree. C or kept on ice. This increase is completely blocked by the addition of F- to the homogenization medium and the assay mixture. The capacity for activation of the reductase is greatest during the early postnatal period and declines as brain maturation proceeds. Catalytic modification of the reductase may play a role in the regulation of cholesterol synthesis in the developing brain.