The neuronal growth cone as a specialized transduction system
- 1 March 1991
- Vol. 13 (3) , 127-134
- https://doi.org/10.1002/bies.950130306
Abstract
Neuronal growth and remodelling are guided by both intracellular gene programs and extracellular stimuli. The growth cone is one site where the effects of these extrinsic and intrinsic factors converge upon the mechanical determinants of cell shape. We review the growth cone as a transduction device, converting extracellular signals into mechanical forces. A variety of soluble, extracellular matrix and membrane bound molecules control growth cone behavior. In addition, GAP‐43 is discussed as a possible component of the Intraneuronal gene program which modulates growth cone activity. The GTP‐binding protein, Go, is a major growth cone membrane protein that may transduce signals not only from outside the cell, but from within as well. This may provide a molecular site in the growth cone for the coordination of a genetic growth program with environmental signals.Keywords
This publication has 109 references indexed in Scilit:
- The product of rab2, a small GTP binding protein, increases neuronal adhesion, and neurite growth in vitroNeuron, 1990
- Axonal guidance in the chick visual system: Posterior tectal membanes induce collapse of growth cones from the temporal retinaNeuron, 1990
- GAP-43 gene expression during development: persistence in a distinctive set of neurons in the mature central nervous systemDevelopmental Brain Research, 1989
- ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neuronsNeuron, 1989
- Spatial and temporal expression pattern of N-cadherin cell adhesion molecules correlated with morphogenetic processes of chicken embryosDevelopmental Biology, 1987
- Assembly of microtubules at the tip of growing axonsNature, 1986
- Distribution of laminin in the developing peripheral nervous system of the chickDevelopmental Biology, 1986
- Polarized compartmentalization of organelles in growth cones from developing optic tectum.The Journal of cell biology, 1985
- Nerve growth cones isolated from fetal rat brain: Subcellular fractionation and characterizationPublished by Elsevier ,1983
- Immunocytochemical evidence for colocalization in neurite growth cones of actin and myosin and their relationship to cell-substratum adhesionsDevelopmental Biology, 1981