Mapping of seven polymorphic loci on human chromosome 13 by in situ hybridization

1 November 1985

journal article
research article
Published by Springer Nature in Human Genetics

Vol. 71 (3) , 192-195
https://doi.org/10.1007/bf00284571

Abstract

Human chromosome 13 loci homologous to seven recombinant DNA probes were mapped using in situ hybridization of ³H-radiolabeled probes to metaphase chromosomes. Each of these seven probes reveals at least one restriction fragment length polymorphism, and thus each probe is potentially valuable in a genetic linkage map of this autosome. The data presented in this paper map the seven loci to specific regions of chromosome 13. This mapping should allow a future comparison of genetic distance with physical distance on this chromosome, and may permit better utilization of these probes in the clinical diagnosis of human chromosomal rearrangements involving chromosome 13.

Keywords

This publication has 11 references indexed in Scilit:

Chromosome 13 restriction fragment length polymorphisms
Human Genetics, 1984
LOCALIZATION OF THE BETA-GLOBIN GENE BY CHROMOSOMAL INSITU HYBRIDIZATION
1984
Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes.
Proceedings of the National Academy of Sciences, 1983
Deficiency of coagulation factors VII and X associated with deletion of a chromosome 13 (q34). Evidence from two cases with 46,XY,t(13;Y)(q11;q34)
Human Genetics, 1982
Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridization
Chromosoma, 1981
An International System for Human Cytogenetic Nomenclature — High-Resolution Banding (1981): ISCN (1981)
Cytogenetic and Genome Research, 1981
Regional Assignment of Genes for Human Esterase D and Retinoblastoma to Chromosome Band 13q14
Science, 1980
CONSTRUCTION OF A GENETIC-LINKAGE MAP IN MAN USING RESTRICTION FRAGMENT LENGTH POLYMORPHISMS
1980
Location of Ribosomal DNA in the Human Chromosome Complement
Proceedings of the National Academy of Sciences, 1972
Chromosome preparations of leukocytes cultured from human peripheral blood
Experimental Cell Research, 1960