REM Sleep Behavior Disorder and REM Sleep Without Atonia in Probable Alzheimer Disease

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Abstract
To determine the frequency of rapid eye movement (REM) sleep behavior disorder (RBD) and REM sleep without atonia among patients with Alzheimer disease and control subjects. Overnight polysomnography. Sleep laboratory. Fifteen patients with probable Alzheimer disease (mean age ± SD, 70.2 ± 5.6) and 15 age-matched healthy control subjects (mean age ± SD, 67.9 ± 5.4). N/A. Four patients with Alzheimer disease presented REM sleep without atonia. One of these patients had all the polysomnographic features of RBD, including behavioral manifestations during REM sleep. RBD is rare, but REM sleep without atonia is relatively frequent in patients with probable Alzheimer disease, a tauopathy.

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