Abstract
Recent investigations confirm the general rule of vitamin therapy, that a vitamin can relieve only those symptoms caused by its deficiency. The avitaminotic diseases are clinical entities with a definite pattern of symptoms and pathogenesis both in man and in laboratory animals. Experimentation with animals has been invaluable in demonstrating the significance of human symptoms, but the demonstration of a lesion in an acutely fulminating vitamin deficiency experimentally induced in the laboratory animal is not a scientific basis for the assumption of the existence of a similar condition in latent avitaminosis in man. Manifest avitaminotic diseases are rarely if ever encountered in otolaryngology; only the latent are seen. The difference between manifest and latent avitaminosis is that between a complete clinical picture and a picture of a few of its essential parts. The diagnosis is frequently difficult and uncertain even by the therapeutic test with the specific vitamin concerned. The

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