REDUCED EXPRESSION OF THE BRCA1 GENE AND INCREASED CHROMOSOMAL INSTABILITY IN MCF‐7 CELL LINE

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Abstract
Using clonal cell cultures, a significant increase in chromosomal aberrations (aneuplolidy, dicentrics and chromatid breaks) were observed in MCF‐7 cells compared with HeLa. BRCA1 expression was lower in MCF‐7 cells than in HeLa cells. Since BRCA1 is known to play a role in the maintenance of chromosomal integrity, the increase in chromosomal aberrations in MCF‐7 clones suggests that downregulation of BRCA1 expression could be one of the possible mechanisms for increased chromosomal instability in this cell line.

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