NEWER PHARMACOLOGICAL DATA ON OXYPHENBUTAZONE

Open Access
Publisher Website
Google Scholar
Abstract
The development from the antipyretic antipyrine to pyrazolidines with specific anti-inflammatory (Butazolidin [phenylbutazone] and Tanderil [p-hydroxyphenylbutazone]) and uricosuric (Anturan) [sulfinpyrazone] actions is shortly reviewed. The author''s published pharmacological data show that Butazolidin and Tanderil have a good antiphlogistic action in acute experimental edema of the rat paw and in acute exudative formalin-peritonitis as well as in the subchronic inflammatory granuloma. We further mentioned the lacking effect in the ultra-violet erythema in guinea pigs and the weak protection against pain, provoked by radiant heat in the mouse. The slight gastrotropic effect was pointed out and the LD50, which though somewhat lower than that of Butazolidin allows the administration of rather high doses of Tanderil. At last we draw the attention to the quick absorption of the preparation in the intestinal tract and to its especially long half-life time in man. Pharmacological data of other trialists, concerning the anti-phogistic action in further kinds of acute oedma and special inflammations, including proliferative processes were reviewed. Newer experiments of the author''s showed a clear inhibitory effect in the acute car-rageenin- and bolus alba-edema, but scarcely at all in hyperergic albumin edema in the rat paw. Furthermore it inhibited the development of the exudative and adhesive uric acid-peritonitis as well as the inflammation in the AgNO3-gonarthritis and the chronic PPLO-polyarthritis in the rat. Wound healing in the skin and in the axolotl tail is only slightly inhibited by Tanderil, while it shows no effect on regenerative processes in planaria and on cell division in the sea-urchin''s egg. Some pharmacological properties which have corresponding clinical effects were also referred to. As regards the drug''s mechanism of action only mention a few points are mentioned The reduction of capillary permeability, the antagonistic effect of Tanderil observed against certain reactions to histamine, serotonin [5-hydroxytryptamine] bradykinin and hyaluroni-dase, which may play a part in acute inflammations, while in the chronic inflammatory stage the inhibition of the mucopolysaccharide metabolism and of the breakdown of collagen would seem to be of significance.

This publication has 20 references indexed in Scilit: