The Effects of Phenylephrine on the Ciliary Body and Optic Nerve Head Microvasculature in Rabbits

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Abstract
Changes in regional vascular caliber produced by phenylephrine were studied by using the morphometric statistical analysis of the microvas-cular castings of the rabbit eye. Subconjunctival injection of 1% phenylephrine (50 μl) produced localized vasoconstriction in the ciliary body arterioles near the site of injection. Single-dose, topical administration (30 μl, 2.5%) and I.V., systemic administration (500 μg) demonstrated significant vasoconstriction in arterioles to the ciliary body, but no significant effect on arterioles supplying the optic nerve head. However, chronic topical administration of phenylephrine (30 μd daily for 40 days) produced mild but statistically significant vasoconstriction in arterioles to both the ciliary body and the optic nerve head. Chronic, topical administration of phenylephrine, and a adrenergic agonist, may affect the vascular perfusion of the optic nerve head.

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