Expression of the Murine Duchenne Muscular Dystrophy Gene in Muscle and Brain
- 18 March 1988
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 239 (4846) , 1416-1418
- https://doi.org/10.1126/science.3347839
Abstract
Complementary DNA clones were isolated that represent the 5′ terminal 2.5 kilobases of the murine Duchenne muscular dystrophy (Dmd) messenger RNA (mRNA). Mouse Dmd mRNA was detectable in skeletal and cardiac muscle and at a level approximately 90 percent lower in brain. Dmd mRNA is also present, but at much lower than normal levels, in both the muscle and brain of three different strains of dystrophicmdxmice. The identification of Dmd mRNA in brain raises the possibility of a relation between human Duchenne muscular dystrophy (DMD) gene expression and the mental retardation found in some DMD males. These results also provide evidence that themdxmutations are allelic variants of mouseDmdgene mutations.This publication has 23 references indexed in Scilit:
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