A Phenotype–Genotype Approach to Predicting CYP450 and P-Glycoprotein Drug Interactions With the Mixed Inhibitor/Inducer Tipranavir/Ritonavir
- 10 February 2010
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 87 (6) , 735-742
- https://doi.org/10.1038/clpt.2009.253
Abstract
The effects of tipranavir/ritonavir (TPV/r) on hepatic and intestinal P-glycoprotein (P-gp) and cytochrome P450 (CYP) enzyme activity were evaluated in 23 volunteers. The subjects received oral (p.o....Keywords
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