Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae.

Publisher Website
Google Scholar
Abstract
We identified borrrelidin, a member of macrolide antibiotic, as an inhibitor of a cyclindependent kinase of the budding yeast, Cdc28/Cln2. A 50% inhibition concentration (IC50) of borrelidin for Cdc28/Cln2 was 24 μM. In addition, borrelidin arrests both haploid and diploid cells in Gl phase at the point indistinguishable from that of α-mating pheromone, at concentrations not affecting the gross protein synthesis. Although the inhibition of CDK activity may not be a solo cause of the Gl arrest, our results indicate that borrelidin is a potential lead compound for developing novel CDK inhibitors of higher eukaryotes.

This publication has 0 references indexed in Scilit: