Post-Exposure Local Treatment of Mice Infected with Rabies with Two Axonal Flow Inhibitors, Colchicine and Vinblastine

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Abstract
Post-exposure protection of rabies-infected mice was observed by proximal application of axonal flow inhibitors, particularly vinblastine, to the local nerve(s). These observations indicate that rabies virus is transported by the axonal flow of the peripheral nerves to the central nervous system. Both a fixed virus (CVS) and a street (sylvatic) virus were used.

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