Influenza — Interpandemic as Well as Pandemic Disease

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Abstract
Influenza occurs in both pandemic and interpandemic forms. Fortunately, pandemics, defined as worldwide outbreaks of severe disease, occur infrequently. Interpandemic influenza, although less extensive in its impact, occurs virtually every year. Widespread avian infection with influenza A (H5N1) and associated clusters of human disease have aroused concern about the threat of a pandemic, and attention has been appropriately focused on control measures to deal with such an event. However, interpandemic influenza has a substantial effect, both cumulatively and in individual outbreaks, and has much to teach us about transmission, pathogenesis, and potentially effective control measures.Since the H1N1 pandemic of . . .