Studies of L1210 Leukemia. II. Ultrastructural and Cytochemical Changes After Treatment With Cyclophosphamide and Vitamin A2

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Abstract
Transplantation of L1210 leukemic cells into DBA/2J mice produced a systemic leukemia which regressed after treatment with cyclophosphamide. Involution of the spleen was reflected histochemically by disappearance of leukemic cells and an afflux of lysosome-rich macrophages, and, biochemically, by an increase in acid phosphatase activity. The increase in acid phosphatase activity in spleens from mice treated concomitantly with cyclophosphamide and vitamin A appeared enhanced. Numerous multinucleated giant cells were observed during the period of leukemia regression. Some were megakaryocytes, possibly representing reservoirs for the virus particles normally present in the leukemic cells. The role of lysosomal enzymes derived from the invading mac:rophages in the degradation of tumor cells, and the potentiality of lysosomal labilixers to enhance the degradative process of leukemic cells are discussed.

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