Circulating Basophil Counts in Atopic Individuals

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Abstract
Absolute numbers of circulating basophils were measured in 55 atopic and 35 non-atopic individuals, using a flow cytometer for automated cell counting. They were significantly elevated in the atopic group (p < 0.001), but the total leucocyte count was not significantly different between the two groups. Eosinophil counts, which correlated with the number of basophils for both populations, were also significantly raised in the atopic group (p < 0.001). Individual variation in absolute basophil counts was not detected in sequential samples taken at daily intervals over 5 days, in 5 atopies and 4 non-atopies. In addition, no significant variation was detected in 6 atopies and 5 non-atopies over a period of up to 20 months.

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