Sustained Hypertension in the Rat Induced by Chronic Blockade of Nitric Oxide Production
- 1 December 1992
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Hypertension
- Vol. 5 (12_Pt_1) , 919-922
- https://doi.org/10.1093/ajh/5.12.919
Abstract
It is well established that acute systemic blockage of L-arginine conversion to nitric oxide by Nw- nitro-L-arginine methyl ester (L-NAME) and other substituted analogs of L-arginine produces vasoconstriction and elevates the blood pressure. The present study in rats reports that chronic L-NAME injections (185 μmol/L/kg body weight, intraperitoneally; every 12 h) for 4 days produces sustained arterial hypertension which is fully and rapidly reversed by acute administration of excess L-arginine. The magnitude of the hypertension is not different between L-NAME treated rats fed normal or high sodium diets. The results from this simple experimental model suggest that chronic blockade of nitric oxide synthesis results in sustained arterial hypertension that is not enhanced by sodium loading. Am J Hypertens 1992;5:919-922Keywords
This publication has 0 references indexed in Scilit: